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VARAdb: a comprehensive variation annotation database for human.
Pan, Qi; Liu, Yue-Juan; Bai, Xue-Feng; Han, Xiao-Le; Jiang, Yong; Ai, Bo; Shi, Shan-Shan; Wang, Fan; Xu, Ming-Cong; Wang, Yue-Zhu; Zhao, Jun; Chen, Jia-Xin; Zhang, Jian; Li, Xue-Cang; Zhu, Jiang; Zhang, Guo-Rui; Wang, Qiu-Yu; Li, Chun-Quan.
Afiliação
  • Pan Q; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Liu YJ; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Bai XF; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Han XL; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Jiang Y; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Ai B; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Shi SS; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Wang F; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Xu MC; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Wang YZ; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Zhao J; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Chen JX; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Zhang J; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Li XC; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Zhu J; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Zhang GR; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Wang QY; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
  • Li CQ; School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing 163319, China.
Nucleic Acids Res ; 49(D1): D1431-D1444, 2021 01 08.
Article em En | MEDLINE | ID: mdl-33095866
With the study of human diseases and biological processes increasing, a large number of non-coding variants have been identified and facilitated. The rapid accumulation of genetic and epigenomic information has resulted in an urgent need to collect and process data to explore the regulation of non-coding variants. Here, we developed a comprehensive variation annotation database for human (VARAdb, http://www.licpathway.net/VARAdb/), which specifically considers non-coding variants. VARAdb provides annotation information for 577,283,813 variations and novel variants, prioritizes variations based on scores using nine annotation categories, and supports pathway downstream analysis. Importantly, VARAdb integrates a large amount of genetic and epigenomic data into five annotation sections, which include 'Variation information', 'Regulatory information', 'Related genes', 'Chromatin accessibility' and 'Chromatin interaction'. The detailed annotation information consists of motif changes, risk SNPs, LD SNPs, eQTLs, clinical variant-drug-gene pairs, sequence conservation, somatic mutations, enhancers, super enhancers, promoters, transcription factors, chromatin states, histone modifications, chromatin accessibility regions and chromatin interactions. This database is a user-friendly interface to query, browse and visualize variations and related annotation information. VARAdb is a useful resource for selecting potential functional variations and interpreting their effects on human diseases and biological processes.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Genoma Humano / Bases de Dados Genéticas / Locos de Características Quantitativas / Diabetes Mellitus Tipo 2 / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Genoma Humano / Bases de Dados Genéticas / Locos de Características Quantitativas / Diabetes Mellitus Tipo 2 / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China