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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
McQuade, Amanda; Kang, You Jung; Hasselmann, Jonathan; Jairaman, Amit; Sotelo, Alexandra; Coburn, Morgan; Shabestari, Sepideh Kiani; Chadarevian, Jean Paul; Fote, Gianna; Tu, Christina H; Danhash, Emma; Silva, Jorge; Martinez, Eric; Cotman, Carl; Prieto, G Aleph; Thompson, Leslie M; Steffan, Joan S; Smith, Ian; Davtyan, Hayk; Cahalan, Michael; Cho, Hansang; Blurton-Jones, Mathew.
Afiliação
  • McQuade A; Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, 92697, USA.
  • Kang YJ; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, 92697, USA.
  • Hasselmann J; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, 92697, USA.
  • Jairaman A; Department of Mechanical Engineering and Engineering Science, University of North Carolina Charlotte, Charlotte, NC, 28223, USA.
  • Sotelo A; Department of Biological Sciences, University of North Carolina Charlotte, Charlotte, NC, 28223, USA.
  • Coburn M; Nanoscale Science Program, University of North Carolina Charlotte, Charlotte, NC, 28223, USA.
  • Shabestari SK; Center for Biomedical Engineering and Science, University of North Carolina Charlotte, Charlotte, NC, 28223, USA.
  • Chadarevian JP; Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, 92697, USA.
  • Fote G; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, 92697, USA.
  • Tu CH; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, 92697, USA.
  • Danhash E; Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, 92697, USA.
  • Silva J; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, 92697, USA.
  • Martinez E; Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, 92697, USA.
  • Cotman C; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, 92697, USA.
  • Prieto GA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, 92697, USA.
  • Thompson LM; Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, 92697, USA.
  • Steffan JS; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, 92697, USA.
  • Smith I; Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, 92697, USA.
  • Davtyan H; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, 92697, USA.
  • Cahalan M; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, 92697, USA.
  • Cho H; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, 92697, USA.
  • Blurton-Jones M; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, 92697, USA.
Nat Commun ; 11(1): 5370, 2020 10 23.
Article em En | MEDLINE | ID: mdl-33097708
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Regulação da Expressão Gênica / Microglia / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Regulação da Expressão Gênica / Microglia / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos