Actinomycin D causes oocyte maturation failure by inhibiting chromosome separation and spindle assembly.

Li, Tianjie; Liu, Changyu; Zhen, Xiumei; Yu, Yang; Qiao, Jie

Actinomycin D causes oocyte maturation failure by inhibiting chromosome separation and spindle assembly.

Li, Tianjie; Liu, Changyu; Zhen, Xiumei; Yu, Yang; Qiao, Jie.

Afiliação

Li T; Department of Obstetrics and Gynecology, Beijing Key laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.
Liu C; Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zhen X; Department of Obstetrics and Gynecology, Beijing Key laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.
Yu Y; Department of Obstetrics and Gynecology, Beijing Key laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.
Qiao J; Department of Obstetrics and Gynecology, Beijing Key laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.

Biol Reprod ; 104(1): 94-105, 2021 01 04.

Article em En | MEDLINE | ID: mdl-33106855

Assuntos

Segregação de Cromossomos/efeitos dos fármacos; Dactinomicina/farmacologia; Oócitos/efeitos dos fármacos; Oogênese/efeitos dos fármacos; Fuso Acromático/efeitos dos fármacos; Animais; Dano ao DNA/efeitos dos fármacos; Humanos; Técnicas de Maturação in Vitro de Oócitos; Camundongos; Camundongos Endogâmicos ICR; Oócitos/crescimento & desenvolvimento

Palavras-chave

actinomycin D; maturation; mitochondrial function; oocyte; oxidative stress; spindle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oócitos / Oogênese / Segregação de Cromossomos / Dactinomicina / Fuso Acromático Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Biol Reprod Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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