Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells.
Acta Biochim Pol
; 67(4): 605-611, 2020 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-33108147
ABSTRACT
In the present study, we investigated the influence of resveratrol on PhIP treated human colon cancer cells and compared the effect to HaCaT cells considered as normal, human keratinocytes. Our results show that resveratrol decreases DNA damage in both cell types, it increases the sensitivity of LoVo cells to apoptosis and has no effect on PhIP-treated HaCaT cells. We confirm that PhIP-induced apoptosis is p53 and caspase 3/7 dependent. Interestingly, normal cells such as HaCaT, which lack functional p53 are more resistant to PhIP treatment.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Carcinógenos
/
Apoptose
/
Resveratrol
/
Imidazóis
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
Acta Biochim Pol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Polônia