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Screening for Diabetic Retinopathy Using an Automated Diagnostic System Based on Deep Learning: Diagnostic Accuracy Assessment.
Rêgo, Sílvia; Dutra-Medeiros, Marco; Soares, Filipe; Monteiro-Soares, Matilde.
Afiliação
  • Rêgo S; R&D Department, Fraunhofer Portugal AICOS, Porto, Portugal, silvia.s.rego@gmail.com.
  • Dutra-Medeiros M; Faculty of Medicine of the University of Porto, Porto, Portugal, silvia.s.rego@gmail.com.
  • Soares F; Department of Surgical Retina, Lisbon Central Hospital, Lisbon, Portugal.
  • Monteiro-Soares M; Portuguese Retina Institute, Lisbon, Portugal.
Ophthalmologica ; 244(3): 250-257, 2021.
Article em En | MEDLINE | ID: mdl-33120397
PURPOSE: To evaluate the diagnostic accuracy of a diagnostic system software for the automated screening of diabetic retinopathy (DR) on digital colour fundus photographs, the 2019 Convolutional Neural Network (CNN) model with Inception-V3. METHODS: In this cross-sectional study, 295 fundus images were analysed by the CNN model and compared to a panel of ophthalmologists. Images were obtained from a dataset acquired within a screening programme. Diagnostic accuracy measures and respective 95% CI were calculated. RESULTS: The sensitivity and specificity of the CNN model in diagnosing referable DR was 81% (95% CI 66-90%) and 97% (95% CI 95-99%), respectively. Positive predictive value was 86% (95% CI 72-94%) and negative predictive value 96% (95% CI 93-98%). The positive likelihood ratio was 33 (95% CI 15-75) and the negative was 0.20 (95% CI 0.11-0.35). Its clinical impact is demonstrated by the change observed in the pre-test probability of referable DR (assuming a prevalence of 16%) to a post-test probability for a positive test result of 86% and for a negative test result of 4%. CONCLUSION: A CNN model negative test result safely excludes DR, and its use may significantly reduce the burden of ophthalmologists at reading centres.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Retinopatia Diabética / Aprendizado Profundo Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans Idioma: En Revista: Ophthalmologica Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Retinopatia Diabética / Aprendizado Profundo Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans Idioma: En Revista: Ophthalmologica Ano de publicação: 2021 Tipo de documento: Article