Evoked potentials predict the clinical changes in a multiple sclerosis drug study.
Neurology
; 37(11): 1754-61, 1987 Nov.
Article
em En
| MEDLINE
| ID: mdl-3313101
ABSTRACT
Visual, brainstem auditory, and median nerve somatosensory evoked potential (EP) tests were performed annually during a 3-year, double-blind, placebo-controlled study of azathioprine with or without steroids in chronic progressive MS. Treatment-related visual and somatosensory EP changes became statistically different 1 year before corresponding differences were seen in the Standard Neurological Examination scores. The statistical significance of EP changes was substantially greater than seen for changes in other clinical scales. The degree of significance was increased by using EP latency values, rather than simple criteria for change. EPs are sensitive, objective measurements useful in MS therapeutic trials.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Azatioprina
/
Metilprednisolona
/
Esclerose Múltipla
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
1987
Tipo de documento:
Article