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Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection.
Li, Wei; Chen, Chuan; Drelich, Aleksandra; Martinez, David R; Gralinski, Lisa E; Sun, Zehua; Schäfer, Alexandra; Kulkarni, Swarali S; Liu, Xianglei; Leist, Sarah R; Zhelev, Doncho V; Zhang, Liyong; Kim, Ye-Jin; Peterson, Eric C; Conard, Alex; Mellors, John W; Tseng, Chien-Te K; Falzarano, Darryl; Baric, Ralph S; Dimitrov, Dimiter S.
Afiliação
  • Li W; Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, PA 15261; LIWEI171@pitt.edu mit666666@pitt.edu.
  • Chen C; Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, PA 15261.
  • Drelich A; Department of Microbiology and Immunology, Centers for Biodefense and Emerging Diseases, Galveston National Laboratory, Galveston, TX 77550.
  • Martinez DR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  • Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  • Sun Z; Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, PA 15261.
  • Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  • Kulkarni SS; Department of Veterinary Microbiology, Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
  • Liu X; Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, PA 15261.
  • Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  • Zhelev DV; Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, PA 15261.
  • Zhang L; Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, PA 15261.
  • Kim YJ; Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, PA 15261.
  • Peterson EC; Abound Bio, Pittsburgh, PA 15219.
  • Conard A; Abound Bio, Pittsburgh, PA 15219.
  • Mellors JW; Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, PA 15261.
  • Tseng CK; Abound Bio, Pittsburgh, PA 15219.
  • Falzarano D; Department of Microbiology and Immunology, Centers for Biodefense and Emerging Diseases, Galveston National Laboratory, Galveston, TX 77550.
  • Baric RS; Department of Veterinary Microbiology, Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
  • Dimitrov DS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Proc Natl Acad Sci U S A ; 117(47): 29832-29838, 2020 11 24.
Article em En | MEDLINE | ID: mdl-33139569
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / Teste Sorológico para COVID-19 / COVID-19 Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / Teste Sorológico para COVID-19 / COVID-19 Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article