Spindle cell neoplasm with EML4-ALK gene fusion presenting as an intraosseous vertebral mass.
Genes Chromosomes Cancer
; 60(4): 282-286, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33170538
ABSTRACT
In this article, we describe a spindle cell neoplasm harboring an EML4-ALK gene fusion presenting as an intraosseous vertebral mass with extension into the adjacent soft tissue in a 65-year-old man. Histologically, the lesion was characterized by the presence of monotonous, cytologically bland spindle cells with loose myxoedematous stroma and interspersed areas of amianthoid-like collagen fiber deposition. Immunohistochemistry demonstrated strong diffuse staining for CD34 and S100, with absent immunoreactivity for SOX10. At 1 year of follow-up after resection, there is no evidence of local recurrence or metastatic disease. This case adds to the clinical and pathologic spectrum of the recently described group of kinase fusion-positive spindle cell neoplasms and represents the first reported intra-osseous example. The presence of ALK rearrangement in this lesion represents a potential therapeutic target, if clinically indicated.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Coluna Vertebral
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Proteínas de Fusão Oncogênica
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Neoplasias de Tecido Conjuntivo
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
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Humans
/
Male
Idioma:
En
Revista:
Genes Chromosomes Cancer
Assunto da revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos