Functional and clinical significance of ROR1 in lung adenocarcinoma.
BMC Cancer
; 20(1): 1085, 2020 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-33172431
ABSTRACT
BACKGROUND:
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is normally detectable in embryonic tissues and absent in adult tissues. ROR1 was shown to inhibit apoptosis, potentiate EGFR signaling and reported to be overexpressed and associated with poor prognosis in several tumor models. This study aimed to assess the expression of ROR1 in lung adenocarcinoma (AC) patients.METHODS:
We analyzed ROR1 expression by quantitative real-time PCR (qRT-PCR) in 56 histologically confirmed lung AC, stage I to IV, in addition we evaluated its association with TTF-1 (thyroid transcription factor-1) expression and the main molecular alterations involved in lung cancerogenesis.RESULTS:
ROR1 overexpression was observed in 28.6% of the entire cohort, using a cut-off of 1, or in 51.8% of the cases using the median value as threshold. Among patients without any genetic alteration, ROR1 overexpression was observed in 34.8% considering a cut-off of 1 and 52.2% considering the median value. The distribution of ROR1 was homogeneous among the different molecular categories we found no association of ROR1 expression and the presence of gene mutations/rearrangements or the expression of TTF-1.CONCLUSIONS:
ROR1 overexpression could constitute a potential therapeutic target because altered in a consistent number of lung AC, especially in cases without druggable genetic alterations. ROR1 expression is independent of classical lung cancer molecular alterations and not correlated, in a Caucasian cohort, to TTF-1 expression.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Rearranjo Gênico
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Biomarcadores Tumorais
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Regulação Neoplásica da Expressão Gênica
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Receptores Órfãos Semelhantes a Receptor Tirosina Quinase
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Adenocarcinoma de Pulmão
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Neoplasias Pulmonares
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Mutação
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BMC Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Suíça