NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor.
J Immunol
; 205(12): 3408-3418, 2020 12 15.
Article
em En
| MEDLINE
| ID: mdl-33177158
ABSTRACT
The RIG-I receptor induces the innate antiviral responses upon sensing RNA viruses. The mechanisms through which RIG-I optimizes the strength of the downstream signaling remain incompletely understood. In this study, we identified that NSUN5 could potentiate the RIG-I innate signaling pathway. Deficiency of NSUN5 enhanced RNA virus proliferation and inhibited the induction of the downstream antiviral genes. Consistently, NSUN5-deficient mice were more susceptible to RNA virus infection than their wild-type littermates. Mechanistically, NSUN5 bound directly to both viral RNA and RIG-I, synergizing the recognition of dsRNA by RIG-I. Collectively, to our knowledge, this study characterized NSUN5 as a novel RIG-I coreceptor, playing a vital role in restricting RNA virus infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
TRNA Metiltransferases
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Infecções por Vírus de RNA
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Vírus de RNA
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RNA de Cadeia Dupla
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RNA Viral
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Receptores Imunológicos
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Proteína DEAD-box 58
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Metiltransferases
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Proteínas Musculares
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China