Engeletin ameliorates pulmonary fibrosis through endoplasmic reticulum stress depending on lnc949-mediated TGF-ß1-Smad2/3 and JNK signalling pathways.

Zhang, Jinjin; Chen, Xiaoqing; Chen, Hongbin; Li, Rongrong; Xu, Pan; Lv, Changjun; Liu, Bo; Song, Xiaodong

Zhang, Jinjin; Chen, Xiaoqing; Chen, Hongbin; Li, Rongrong; Xu, Pan; Lv, Changjun; Liu, Bo; Song, Xiaodong.

Afiliação

Zhang J; Department of Cellular and Genetic Medicine, School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, China.
Chen X; Department of Respiratory Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Chen H; Department of Cellular and Genetic Medicine, School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, China.
Li R; Department of Respiratory Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Xu P; Department of Respiratory Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Lv C; Department of Cellular and Genetic Medicine, School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, China.
Liu B; Department of Respiratory Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Song X; Department of Respiratory Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.

Pharm Biol ; 58(1): 1105-1114, 2020 Dec.

Article em En | MEDLINE | ID: mdl-33181025

Assuntos

Estresse do Retículo Endoplasmático/efeitos dos fármacos; Flavonóis/farmacologia; Glicosídeos/farmacologia; Fibrose Pulmonar/tratamento farmacológico; RNA Longo não Codificante/genética; Animais; Bleomicina; Linhagem Celular; Técnicas de Silenciamento de Genes; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Fibrose Pulmonar/genética; Fibrose Pulmonar/patologia; Proteína Smad2/metabolismo; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

ER stress; PERK-ATF4 signalling pathway; PF; RNA sequence; lncRNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Flavonóis / Estresse do Retículo Endoplasmático / RNA Longo não Codificante / Glicosídeos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Pharm Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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