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APOE Genotype Disclosure and Lifestyle Advice in a Randomized Intervention Study with Finnish Participants.
Leskinen, Heidi M; Tringham, Maaria; Karjalainen, Heli; Iso-Touru, Terhi K; Hietaranta-Luoma, Hanna-Leena; Marnila, Pertti J; Pihlava, Juha-Matti; Hurme, Timo; Kankaanpää, Santeri J; Puolijoki, Hannu; Åkerman, Kari; Tanner, Laura; Sandell, Mari; Vähäkangas, Kirsi; Hopia, Anu; Tahvonen, Raija; Rokka, L Susanna.
Afiliação
  • Leskinen HM; Production Systems, Natural Resources Institute Finland (Luke), Jokioinen, Finland.
  • Tringham M; Functional Foods Forum, Faculty of Medicine, University of Turku, Turku, Finland.
  • Karjalainen H; Functional Foods Forum, Faculty of Medicine, University of Turku, Turku, Finland.
  • Iso-Touru TK; Production Systems, Natural Resources Institute Finland (Luke), Jokioinen, Finland.
  • Hietaranta-Luoma HL; Functional Foods Forum, Faculty of Medicine, University of Turku, Turku, Finland.
  • Marnila PJ; Production Systems, Natural Resources Institute Finland (Luke), Jokioinen, Finland.
  • Pihlava JM; Production Systems, Natural Resources Institute Finland (Luke), Jokioinen, Finland.
  • Hurme T; Natural Resources, Natural Resources Institute Finland (Luke), Jokioinen, Finland.
  • Kankaanpää SJ; Production Systems, Natural Resources Institute Finland (Luke), Jokioinen, Finland.
  • Puolijoki H; The Hospital District of South Ostrobothnia, Seinäjoki, Finland.
  • Åkerman K; The Hospital District of South Ostrobothnia, Seinäjoki, Finland.
  • Tanner L; Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland.
  • Sandell M; Functional Foods Forum, Faculty of Medicine, University of Turku, Turku, Finland.
  • Vähäkangas K; Department of Food and Nutrition, University of Helsinki, Helsinki, Finland.
  • Hopia A; School of Pharmacy/Toxicology, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
  • Tahvonen R; Functional Foods Forum, Faculty of Medicine, University of Turku, Turku, Finland.
  • Rokka LS; Production Systems, Natural Resources Institute Finland (Luke), Jokioinen, Finland.
J Nutr ; 151(1): 85-97, 2021 01 04.
Article em En | MEDLINE | ID: mdl-33188400
BACKGROUND: The APOE ε4 allele is associated with higher risks of cardiovascular diseases and Alzheimer disease than ε3 and ε2. OBJECTIVES: We studied the effectiveness of dietary and lifestyle guidance and personal genetic risk information [ε4 carrier (ε4+); ε4 noncarrier (ε4-)] as motivators for a healthier lifestyle. METHODS: A total of 188 healthy Finnish volunteers (82.4% women; mean ± SD age: 51.0 ± 5.6 y; BMI: 26.0 ± 3.6 kg/m2; total cholesterol: 5.2 ± 0.9 mmol/L) participated in our randomized intervention study. The participants were genotyped for APOE and divided into intervention (INT; INTε4+, n = 33; INTε4-, n = 57) and control groups (CTRL; CTRLε4+, n = 36; CTRLε4-, n = 62). Blood samples, measured observations, and questionnaire data were obtained at baseline and at 1 and 1.5 y. INT participants received their ε4 carrier status at baseline. Monthly Internet-based guidance based on the Finnish Dietary guidelines was provided for all. RESULTS: The proportion of SFAs in plasma over time fluctuated less in INTε4+ than in the other groups (P-interaction < 0.05; primary outcome). The lifestyle guidance increased vegetable consumption from 3.5 to 3.6 portions/d, improved the dietary fat quality score by 5.3%, increased the plasma n-3 (ω-3) FA proportion by 7.3%, and decreased the consumption of high-fat/high-sugar foods from 7.3 to 6.5 portions/wk and total- and LDL-cholesterol concentrations by 4.3% and 6.1%, respectively, in the entire participant population (P < 0.05; secondary outcome). Compared with the ε4- participants, ε4+ participants had 2.4% higher plasma n-6 (ω-6) FA, lower C-peptide (3.9 compared with 4.2 nmol/L × h) and sensitive C-reactive protein values, and decreased plasma malondialdehyde concentrations over time (P < 0.05; secondary outcome). CONCLUSIONS: Lifestyle guidance given to healthy Finnish participants yielded small but beneficial changes. The INTε4+ group did not seem markedly more responsive to the guidance than the other groups.This trial was registered at clinicaltrials.gov as NCT03794141.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Doenças Cardiovasculares / Predisposição Genética para Doença / Aconselhamento / Estilo de Vida Tipo de estudo: Clinical_trials / Guideline / Qualitative_research Limite: Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: J Nutr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Finlândia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Doenças Cardiovasculares / Predisposição Genética para Doença / Aconselhamento / Estilo de Vida Tipo de estudo: Clinical_trials / Guideline / Qualitative_research Limite: Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: J Nutr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Finlândia