Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux.

Bormio Nunes, Julia H; Hager, Sonja; Mathuber, Marlene; Pósa, Vivien; Roller, Alexander; Enyedy, Éva A; Stefanelli, Alessia; Berger, Walter; Keppler, Bernhard K; Heffeter, Petra; Kowol, Christian R

Bormio Nunes, Julia H; Hager, Sonja; Mathuber, Marlene; Pósa, Vivien; Roller, Alexander; Enyedy, Éva A; Stefanelli, Alessia; Berger, Walter; Keppler, Bernhard K; Heffeter, Petra; Kowol, Christian R.

Afiliação

Bormio Nunes JH; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, Vienna 1090, Austria.
Hager S; Inorganic Chemistry Department, Institute of Chemistry, University of Campinas - UNICAMP, Campinas, São Paulo 13083-970, Brazil.
Mathuber M; Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria.
Pósa V; Research Cluster "Translational Cancer Therapy Research", Vienna 1090, Austria.
Roller A; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, Vienna 1090, Austria.
Enyedy ÉA; Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre and MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged H-6720, Hungary.
Stefanelli A; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, Vienna 1090, Austria.
Berger W; Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre and MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged H-6720, Hungary.
Keppler BK; Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria.
Heffeter P; Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria.
Kowol CR; Research Cluster "Translational Cancer Therapy Research", Vienna 1090, Austria.

J Med Chem ; 63(22): 13719-13732, 2020 11 25.

Article em En | MEDLINE | ID: mdl-33190481

Assuntos

Aminoquinolinas/metabolismo; Cobre/metabolismo; Resistencia a Medicamentos Antineoplásicos/fisiologia; Glutationa/metabolismo; Líquido Intracelular/metabolismo; Proteínas Associadas à Resistência a Múltiplos Medicamentos/metabolismo; Tiossemicarbazonas/metabolismo; Aminoquinolinas/química; Aminoquinolinas/farmacologia; Antineoplásicos/química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Cobre/química; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Glutationa/química; Humanos; Líquido Intracelular/efeitos dos fármacos; Tiossemicarbazonas/química; Tiossemicarbazonas/farmacologia; Difração de Raios X

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiossemicarbazonas / Resistencia a Medicamentos Antineoplásicos / Cobre / Proteínas Associadas à Resistência a Múltiplos Medicamentos / Glutationa / Aminoquinolinas / Líquido Intracelular Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Áustria

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