A theory of carcinogenesis based on an analysis of the effects of carcinogens.
Med Hypotheses
; 24(3): 265-86, 1987 Nov.
Article
em En
| MEDLINE
| ID: mdl-3320696
ABSTRACT
Carcinogenic stimuli appear to act on target cells (and their daughters) by one or more of three mechanisms. The first is by oxidation of membrane component molecules on the extracellular surfaces of their plasma membranes. The second is by chronic and continuous impingement of electrons on the extracellular surfaces of their plasma membranes and the third is by relocation of predominantly basic molecules to the cytoplasmic surfaces of their plasma membranes. This latter effect in turn causes electrostatic attraction of image charged acidic molecules to the extracellular surfaces to balance the transmembrane charge of the target cells. Each of the above mechanisms results in a condition of increased electronegativity of the extracellular surfaces of plasma membranes of the target cells and their daughters. A theory of transformation is advanced based on the above related modes of action and it is used to explain some previously unexplainable properties of tumors.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Carcinógenos
/
Transformação Celular Neoplásica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Med Hypotheses
Ano de publicação:
1987
Tipo de documento:
Article