Possible Participation of Ionotropic Glutamate Receptors and l-Arginine-Nitric Oxide-Cyclic Guanosine Monophosphate-ATP-Sensitive K<sup>+</sup> Channel Pathway in the Antinociceptive Activity of Cardamonin in Acute Pain Animal Models.

Pui Ping, Chung; Akhtar, Muhammad Nadeem; Israf, Daud Ahmad; Perimal, Enoch Kumar; Sulaiman, Mohd Roslan

Possible Participation of Ionotropic Glutamate Receptors and l-Arginine-Nitric Oxide-Cyclic Guanosine Monophosphate-ATP-Sensitive K⁺ Channel Pathway in the Antinociceptive Activity of Cardamonin in Acute Pain Animal Models.

Pui Ping, Chung; Akhtar, Muhammad Nadeem; Israf, Daud Ahmad; Perimal, Enoch Kumar; Sulaiman, Mohd Roslan.

Afiliação

Pui Ping C; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Akhtar MN; Faculty of Industrial Sciences & Technology, University Malaysia Pahang, Gambang 26300, Pahang, Malaysia.
Israf DA; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Perimal EK; Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Sulaiman MR; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang 43400, Selangor, Malaysia.

Molecules ; 25(22)2020 Nov 18.

Article em En | MEDLINE | ID: mdl-33217904

Assuntos

Dor Aguda/tratamento farmacológico; Trifosfato de Adenosina/metabolismo; Arginina/metabolismo; Chalconas/uso terapêutico; Guanosina Monofosfato/metabolismo; Canais KATP/metabolismo; Óxido Nítrico/metabolismo; Receptores Ionotrópicos de Glutamato/metabolismo; Analgésicos/farmacologia; Analgésicos/uso terapêutico; Animais; Chalconas/farmacologia; Modelos Animais de Doenças; Maleato de Dizocilpina/farmacologia; Glibureto/farmacologia; Masculino; Camundongos Endogâmicos ICR; Nociceptividade/efeitos dos fármacos; Proteína Quinase C/metabolismo; Quinoxalinas/farmacologia

Palavras-chave

acute pain; cGMP; cardamonin; glutamate receptor; l-arginine nitric oxide pathway; potassium channels

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arginina / Trifosfato de Adenosina / Guanosina Monofosfato / Chalconas / Canais KATP / Receptores Ionotrópicos de Glutamato / Dor Aguda / Óxido Nítrico Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Malásia

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