Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine.

Fukuhara, Natsumi; Honda, Yuto; Ukita, Nao; Matsui, Makoto; Miura, Yutaka; Hoshina, Katsuyuki

Fukuhara, Natsumi; Honda, Yuto; Ukita, Nao; Matsui, Makoto; Miura, Yutaka; Hoshina, Katsuyuki.

Afiliação

Fukuhara N; Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Honda Y; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Ukita N; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Matsui M; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Miura Y; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Hoshina K; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.

Int J Mol Sci ; 21(22)2020 Nov 18.

Article em En | MEDLINE | ID: mdl-33218045

Assuntos

Aneurisma da Aorta Abdominal/tratamento farmacológico; Sistemas de Liberação de Medicamentos; Inibidores de Hidroximetilglutaril-CoA Redutases; Nanopartículas; Animais; Aneurisma da Aorta Abdominal/induzido quimicamente; Aneurisma da Aorta Abdominal/metabolismo; Aneurisma da Aorta Abdominal/patologia; Modelos Animais de Doenças; Inibidores de Hidroximetilglutaril-CoA Redutases/química; Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia; Macrófagos/metabolismo; Macrófagos/patologia; Masculino; Metaloproteinase 9 da Matriz/metabolismo; Micelas; Nanopartículas/química; Nanopartículas/uso terapêutico; Ratos; Ratos Sprague-Dawley

Palavras-chave

abdominal aortic aneurysm; drug delivery; polymeric micelle; statin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Aneurisma da Aorta Abdominal / Inibidores de Hidroximetilglutaril-CoA Redutases / Nanopartículas Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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