Cryo-EM structures and functional characterization of homo- and heteropolymers of human ferritin variants.

Irimia-Dominguez, Jose; Sun, Chen; Li, Kunpeng; Muhoberac, Barry B; Hallinan, Grace I; Garringer, Holly J; Ghetti, Bernardino; Jiang, Wen; Vidal, Ruben

Irimia-Dominguez, Jose; Sun, Chen; Li, Kunpeng; Muhoberac, Barry B; Hallinan, Grace I; Garringer, Holly J; Ghetti, Bernardino; Jiang, Wen; Vidal, Ruben.

Afiliação

Irimia-Dominguez J; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Dr., MSB A136, Indianapolis, IN, 46202, USA. jidominguez@coh.org.
Sun C; Department of Molecular and Cellular Endocrinology, Beckman Research Institute, City of Hope, 1500 E. Duarte Road, Gonda North, Bay 3131E, Duarte, CA, 91010, USA. jidominguez@coh.org.
Li K; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, 47906, USA.
Muhoberac BB; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, 47906, USA.
Hallinan GI; Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202, USA.
Garringer HJ; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Dr., MSB A136, Indianapolis, IN, 46202, USA.
Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Dr., MSB A136, Indianapolis, IN, 46202, USA.
Jiang W; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Dr., MSB A136, Indianapolis, IN, 46202, USA.
Vidal R; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Sci Rep ; 10(1): 20666, 2020 11 26.

Article em En | MEDLINE | ID: mdl-33244127

Assuntos

Apoferritinas/metabolismo; Ferro/metabolismo; Polímeros/metabolismo; Apoferritinas/genética; Encéfalo/metabolismo; Microscopia Crioeletrônica/métodos; Homeostase/genética; Homeostase/fisiologia; Humanos; Distúrbios do Metabolismo do Ferro/genética; Distúrbios do Metabolismo do Ferro/metabolismo; Mutação/genética; Distrofias Neuroaxonais/genética; Distrofias Neuroaxonais/metabolismo; Doenças Neurodegenerativas/genética; Doenças Neurodegenerativas/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoferritinas / Polímeros / Ferro Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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