The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude.
Nutrients
; 12(12)2020 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-33255790
ABSTRACT
Hypoxia induced by low O2 pressure is responsible for several physiological and behavioral alterations. Changes in physiological systems are frequent, including inflammation and psychobiological declines such as mood and cognition worsening, resulting in increased reaction time, difficulty solving problems, reduced memory and concentration. The paper discusses the possible relationship between glutamine supplementation and worsening cognition mediated by inflammation induced by high altitude hypoxia. The paper is a narrative literature review conducted to verify the effects of glutamine supplementation on psychobiological aspects. We searched MEDLINE/PubMed and Web of Science databases and gray literature by Google Scholar for English articles. Mechanistic pathways mediated by glutamine suggest potential positive effects of its supplementation on mood and cognition, mainly its potential effect on inflammation. However, clinical studies are scarce, making any conclusions impossible. Although glutamine plays an important role and seems to mitigate inflammation, clinical studies should test this hypothesis, which will contribute to a better mood and cognition state for several people who suffer from problems mediated by hypoxia.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Afeto
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Altitude
/
Glutamina
/
Hipóxia
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Nutrients
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil