A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
Proc Natl Acad Sci U S A
; 117(50): 32029-32037, 2020 12 15.
Article
em En
| MEDLINE
| ID: mdl-33257580
ABSTRACT
Disease tolerance, the capacity of tissues to withstand damage caused by a stimulus without a decline in host fitness, varies across tissues, environmental conditions, and physiologic states. While disease tolerance is a known strategy of host defense, its role in noninfectious diseases has been understudied. Here, we provide evidence that a thermogenic fat-epithelial cell axis regulates intestinal disease tolerance during experimental colitis. We find that intestinal disease tolerance is a metabolically expensive trait, whose expression is restricted to thermoneutral mice and is not transferable by the microbiota. Instead, disease tolerance is dependent on the adrenergic state of thermogenic adipocytes, which indirectly regulate tolerogenic responses in intestinal epithelial cells. Our work has identified an unexpected mechanism that controls intestinal disease tolerance with implications for colitogenic diseases.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo Marrom
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Colite
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Neoplasias do Colo
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Infecções por Enterobacteriaceae
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Resistência à Doença
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2020
Tipo de documento:
Article