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Diagnostic Value of TROP2 Expression in Papillary Thyroid Carcinoma.
Saffar, Hana; Jahanbin, Behnaz; Ameli, Fereshteh; Farhang, Fatemeh; Tavangar, Seyed M; Saffar, Hiva.
Afiliação
  • Saffar H; Department of Pathology, Imam Khomeini Hospital Complex.
  • Jahanbin B; Department of Pathology, Imam Khomeini Hospital Complex.
  • Ameli F; Department of Pathology, Imam Khomeini Hospital Complex.
  • Farhang F; Department of Pathology, Imam Khomeini Hospital Complex.
  • Tavangar SM; Department of Pathology Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Saffar H; Department of Pathology Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Appl Immunohistochem Mol Morphol ; 29(3): 218-222, 2021 03 01.
Article em En | MEDLINE | ID: mdl-33264108
Papillary thyroid carcinoma (PTC) represents the most common primary malignant thyroid lesion in all age groups. As diagnosis of PTC could be challenging in some cases and borderline nuclear features could be seen in some benign mimickers, several immunohistochemical markers are proposed to be helpful for making the correct diagnosis. In this study the authors investigated the diagnostic value of transmembrane glycoprotein (TROP2) for differentiating PTC from other thyroid follicular lesions. A total of 155 total thyroidectomy specimens including 84 cases of PTC and 71 cases of non-PTC were investigated. Among non-PTC group, 45 cases were follicular neoplasms and 26 cases were Hashimoto thyroiditis. TROP2 expression was observed in 82 of 84 cases of PTC group. In contrast only 5 cases of non-PTC group, all from Hashimoto thyroiditis specimens, showed positive expression. The sensitivity, specificity, positive predictive value, and negative predictive value of TROP2 for diagnosis of PTC was 98%, 93%, 94%, and 97%, respectively. The authors concluded that high sensitivity and specificity of TROP2 as well as its uniform negative reaction in follicular adenoma and carcinoma makes it a valuable immunohistochemical marker for diagnosis of PTC.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Biomarcadores Tumorais / Adenoma / Moléculas de Adesão Celular / Câncer Papilífero da Tireoide / Antígenos de Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Appl Immunohistochem Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Biomarcadores Tumorais / Adenoma / Moléculas de Adesão Celular / Câncer Papilífero da Tireoide / Antígenos de Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Appl Immunohistochem Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Ano de publicação: 2021 Tipo de documento: Article