T Cells: Warriors of SARS-CoV-2 Infection.
Trends Immunol
; 42(1): 18-30, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33277181
ABSTRACT
Severe infection with severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is characterized by massive cytokine release and T cell loss. The exaggerated host immune response, incapable of viral clearance, instead aggravates respiratory distress, as well as cardiac, and/or damage to other organs. The mortality pattern of SARS-CoV-2 infection, higher in older versus younger adults and almost absent in children, is possibly caused by the effects of age and pre-existing comorbidities on innate and adaptive immunity. Here, we speculate that the abnormal and excessive immune response to SARS-CoV-2 infection partly depends on T cell immunological memory, which is more pronounced in adults compared with children, and may significantly contribute to immunopathology and massive collateral damage in coronavirus disease 2019 (COVID-19) patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
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Imunidade Adaptativa
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SARS-CoV-2
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COVID-19
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Imunidade Inata
Limite:
Humans
Idioma:
En
Revista:
Trends Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article