Enantioselective Synthesis of (+)-Coerulescine by a Phase-Transfer Catalytic Allylation of Diphenylmethyl tert-Butyl α-(2-Nitrophenyl)Malonate.
Front Chem
; 8: 577371, 2020.
Article
em En
| MEDLINE
| ID: mdl-33282828
ABSTRACT
A 7-step enantioselective synthetic method for preparing (S)(+)-coerulescine is reported through the use of diphenylmethyl tert-butyl α-(2-nitrophenyl)malonate (16% overall yield, >99% ee). Allylation is the key step under phase-transfer catalytic conditions (86% ee). This synthetic method can be used as a practical route for the synthesis of various derivatives of (S)(+)-coerulescine for analyzing its structure-activity relationships against its biological activities.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Front Chem
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Coréia do Sul