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The V2 loop of HIV gp120 delivers costimulatory signals to CD4+ T cells through Integrin α4ß7 and promotes cellular activation and infection.
Goes, Livia R; Sajani, Alia; Sivro, Aida; Olowojesiku, Ronke; Ray, Jocelyn C; Perrone, Ian; Yolitz, Jason; Girard, Alexandre; Leyre, Louise; Wibmer, Constantinos Kurt; Morris, Lynn; Gorini, Giacomo; Franchini, Genoveffa; Mason, Rosemarie D; Roederer, Mario; Mehandru, Saurabh; Soares, Marcelo A; Cicala, Claudia; Fauci, Anthony S; Arthos, James.
Afiliação
  • Goes LR; Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20814; livia.goes@nih.gov afauci@nih.gov.
  • Sajani A; Instituto Nacional de Câncer, Rio de Janeiro, 20231-050, Brazil.
  • Sivro A; Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20814.
  • Olowojesiku R; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 4013 Durban, South Africa.
  • Ray JC; Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20814.
  • Perrone I; Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20814.
  • Yolitz J; Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20814.
  • Girard A; Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20814.
  • Leyre L; Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20814.
  • Wibmer CK; Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Morris L; National Institute for Communicable Diseases of the National Health Laboratory Service, 2192 Johannesburg, South Africa.
  • Gorini G; National Institute for Communicable Diseases of the National Health Laboratory Service, 2192 Johannesburg, South Africa.
  • Franchini G; Animal Models and Vaccine Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814.
  • Mason RD; Animal Models and Vaccine Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814.
  • Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814.
  • Mehandru S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814.
  • Soares MA; Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Cicala C; Instituto Nacional de Câncer, Rio de Janeiro, 20231-050, Brazil.
  • Fauci AS; Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
  • Arthos J; Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD 20814.
Proc Natl Acad Sci U S A ; 117(51): 32566-32573, 2020 12 22.
Article em En | MEDLINE | ID: mdl-33288704
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Proteína gp120 do Envelope de HIV / Infecções por HIV / Integrinas Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Proteína gp120 do Envelope de HIV / Infecções por HIV / Integrinas Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article