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Glucose-lowering activity of dark tea protein extract by modulating spleen-brain axis of diabetic mice.
Su, Keying; Mao, Xinliang; Zhang, Xuewu.
Afiliação
  • Su K; Guangzhou College of Technology and Business, Guangzhou, People's Republic of China.
  • Mao X; School of Food Science and Engineering, South China University of Technology, Guangzhou, People's Republic of China.
  • Zhang X; School of Food Science and Engineering, South China University of Technology, Guangzhou, People's Republic of China.
Br J Nutr ; 126(7): 961-969, 2021 10 14.
Article em En | MEDLINE | ID: mdl-33298209
ABSTRACT
The present study aims to explore the glucose-lowering effects of the previously characterised dark tea (Camellia sinensis L.) protein extract (DTPE) from Heimaojian on the spleen-brain axis of diabetic mice. DTPE was orally administrated (50-100 mg/kg) to alloxan-induced mice for 21 d; a biochemical assay and transcriptome profiling (RNA sequencing (RNA-Seq)) were performed. The results showed that DTPE can improve glucose tolerance. Compared with the model group, at day 21, the fasting blood glucose values were significantly (P < 0·05) decreased by 44·9 % (13·8 v. 7·6 mmol/l) and 51·4 % (13·8 v. 6·7 mmol/l) for high dose of DTPE (100 mg/kg) and drug metformin (125 mg/kg) groups, respectively. Subsequently, transcriptome profiling (RNA-Seq) was performed on the spleen and brain of diabetic mice. Totally, fifty-two spleen-derived and forty-seven brain-derived differentially expressed genes related to the synthesis, transport and metabolism of glucose were identified. The regulatory network analysis indicated that DTPE may exert glucose-lowering effects through a thirty-seven-gene sub-network related to metabolism, Parkinson's disease, oxidative phosphorylation and immunity. In summary, for the first time, the present data revealed that dark tea-derived DTPE could exert a potential anti-hyperglycaemic effect by modulating the spleen-brain axis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Chá / Extratos Vegetais / Camellia sinensis / Diabetes Mellitus Experimental Limite: Animals Idioma: En Revista: Br J Nutr Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Chá / Extratos Vegetais / Camellia sinensis / Diabetes Mellitus Experimental Limite: Animals Idioma: En Revista: Br J Nutr Ano de publicação: 2021 Tipo de documento: Article