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Antioxidant and Biological Activities of Hydroxytyrosol and Homovanillic Alcohol Obtained from Olive Mill Wastewaters of Extra-Virgin Olive Oil Production.
Ricelli, Alessandra; Gionfra, Fabio; Percario, Zulema; De Angelis, Martina; Primitivo, Ludovica; Bonfantini, Veronica; Antonioletti, Roberto; Bullitta, Simonetta Maria; Saso, Luciano; Incerpi, Sandra; Pedersen, Jens Zacho.
Afiliação
  • Ricelli A; Institute of Molecular Biology and Pathology-CNR I-00185 Roma, Italy.
  • Gionfra F; Dept Sciences, University Roma Tre, I-00146 Roma, Italy.
  • Percario Z; Dept Sciences, University Roma Tre, I-00146 Roma, Italy.
  • De Angelis M; Institute of Molecular Biology and Pathology-CNR I-00185 Roma, Italy.
  • Primitivo L; Dept Chemistry, University "Sapienza", I-00185 Roma, Italy.
  • Bonfantini V; Institute of Molecular Biology and Pathology-CNR I-00185 Roma, Italy.
  • Antonioletti R; Dept Chemistry, University "Sapienza", I-00185 Roma, Italy.
  • Bullitta SM; Dept Chemistry, University "Sapienza", I-00185 Roma, Italy.
  • Saso L; Institute of Molecular Biology and Pathology-CNR I-00185 Roma, Italy.
  • Incerpi S; Institute for the Animal Production System in the Mediterranean Environment-CNR, I-07100 Sassari, Italy.
  • Pedersen JZ; Dept Physiology and Pharmacology, University "Sapienza", V. Erspamer I- 00185 Rome, Italy.
J Agric Food Chem ; 68(52): 15428-15439, 2020 Dec 30.
Article em En | MEDLINE | ID: mdl-33305574
Some constituents of the Mediterranean diet, such as extra-virgin olive oil (EVOO) contain substances such as hydroxytyrosol (HT) and its metabolite homovanillic alcohol (HA). HT has aroused much interest due to its antioxidant activity as a radical scavenger, whereas only a few studies have been made on the HA molecule. Both chemical synthesis and extraction techniques have been developed to obtain these molecules, with each method having its advantages and drawbacks. In this study, we report the use of tyrosol from olive mill wastewaters as a starting molecule to synthesize HT and HA, using a sustainable procedure characterized by high efficiency and low cost. The effects of HT and HA were evaluated on two cell lines, THP-1 human leukemic monocytes and L-6 myoblasts from rat skeletal muscle, after treating the cells with a radical generator. Both HT and HA efficiently inhibited ROS production. In particular, HT inhibited the proliferation of the THP-1 leukemic monocytes, while HA protected L-6 myoblasts from cytotoxicity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Álcool Feniletílico / Extratos Vegetais / Águas Residuárias / Ácido Homovanílico / Antioxidantes Limite: Animals / Humans Idioma: En Revista: J Agric Food Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Álcool Feniletílico / Extratos Vegetais / Águas Residuárias / Ácido Homovanílico / Antioxidantes Limite: Animals / Humans Idioma: En Revista: J Agric Food Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália