Prognostic implications of depression and inflammation in patients with metastatic lung cancer.
Future Oncol
; 17(2): 183-196, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-33305608
ABSTRACT
Background:
Lung cancer-related inflammation is associated with depression. Both elevated inflammation and depression are associated with worse survival. However, outcomes of patients with concomitant depression and elevated inflammation are not known. Materials &methods:
Patients with metastatic lung cancer (n = 123) were evaluated for depression and inflammation. Kaplan-Meier plots and Cox proportional hazard models provided survival estimations.Results:
Estimated survival was 515 days for the cohort and 323 days for patients with depression (hazard ratio 1.12; 95% CI 1.05-1.179), 356 days for patients with elevated inflammation (hazard ratio 2.85, 95% CI 1.856-4.388), and 307 days with both (χ2 = 12.546; p < 0.001]).Conclusion:
Depression and inflammation are independently associated with inferior survival. Survival worsened by inflammation is mediated by depression-a treatable risk factor.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Depressão
/
Inflamação
/
Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos