MANAGEMENT OF ENDOCRINE DISEASE: Residual adrenal function in Addison's disease.
Eur J Endocrinol
; 184(2): R61-R67, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33306039
ABSTRACT
Over the last 10 years, evidence has accumulated that autoimmune Addison's disease (AAD) is a heterogeneous disease. Residual adrenal function, characterised by persistent secretion of cortisol, other glucocorticoids and mineralocorticoids is present in around 30% of patients with established AAD, and appears commoner in men. This persistent steroidogenesis is present in some patients with AAD for more than 20 years, but it is commoner in people with shorter disease duration. The clinical significance of residual adrenal function is not fully clear at the moment, but as it signifies an intact adrenocortical stem cell population, it opens up the possibility of regeneration of adrenal steroidogenesis and improvement in adrenal failure for some patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Addison
/
Glândulas Suprarrenais
/
Doenças do Sistema Endócrino
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Endocrinol
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido