Fatty liver is an independent risk factor for gallbladder polyps.
World J Gastroenterol
; 26(44): 6979-6992, 2020 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-33311944
ABSTRACT
BACKGROUND:
Gallbladder polyps (GBPs) are known to be associated with obesity and metabolic diseases. However, to date, the relationship between GBPs and abnormal body fat distribution, such as fatty liver, visceral obesity, or sarcopenia, has not yet been established.AIM:
To evaluate whether GBPs are associated with fatty liver, visceral obesity, or sarcopenia.METHODS:
We retrospectively reviewed the medical records of subjects who underwent various laboratory tests, body composition measurement with a non-invasive body composition analyzer, and abdominal ultrasonography during health checkups. A total of 1405 subjects with GBPs were compared with 2810 age- and sex-matched controls.RESULTS:
The mean age of the subjects was 46.8 ± 11.7 years, and 63.8% were male. According to multiple logistic regression analysis, the presence of fatty liver [odds ratio (OR) 1.413; 95% confidence interval (CI) 1.218-1.638; P < 0.001] was an independent risk factor for GBP, together with low levels of alanine aminotransferase (OR 0.993; 95%CI 0.989-0.996; P < 0.001). Additionally, fatty liver showed both independent (OR 1.629; 95%CI, 1.335-1.988; P < 0.001) and dose-dependent (moderate to severe fatty liver; OR 2.137; 95%CI, 1.662-2.749; P < 0.001) relationship with large GBPs (≥ 5 mm). The presence of sarcopenia and high visceral fat area were not significantly associated with GBPs.CONCLUSION:
Fatty liver was found to be closely associated with GBPs irrespective of sarcopenia and visceral obesity.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fígado Gorduroso
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Doenças da Vesícula Biliar
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
World J Gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Coréia do Sul