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Cognitive effects of low dose of ionizing radiation - Lessons learned and research gaps from epidemiological and biological studies.
Pasqual, Elisa; Boussin, François; Bazyka, Dimitry; Nordenskjold, Arvid; Yamada, Michiko; Ozasa, Kotaro; Pazzaglia, Simonetta; Roy, Laurence; Thierry-Chef, Isabelle; de Vathaire, Florent; Benotmane, Mohammed Abderrafi; Cardis, Elisabeth.
Afiliação
  • Pasqual E; Barcelona Institute for Global Health (ISGlobal), Campus Mar, Barcelona Biomedical Research Park (PRBB), Dr Aiguader 88, 08003 Barcelona, Spain; University Pompeu Fabra, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Healt
  • Boussin F; Université de Paris and Université Paris-Saclay, Inserm, LRP/iRCM/IBFJ CEA, UMR Stabilité Génétique Cellules Souches et Radiations, F-92265 Fontenay-aux-Roses, France.
  • Bazyka D; National Research Center for Radiation Medicine, 53 Illenko str., Kyiv, Ukraine.
  • Nordenskjold A; Department of Clinical Neuroscience, Division of Neurology, Karolinska Institutet, Stockholm, Sweden.
  • Yamada M; Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.
  • Ozasa K; Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan.
  • Pazzaglia S; Laboratory of Biomedical Technologies, ENEA CR-Casaccia, Via Anguillarese 301, 00123 Rome, Italy.
  • Roy L; Department for Research on the Biological and Health Effects of Ionising Radiation. Institut of Radiation Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France.
  • Thierry-Chef I; Barcelona Institute for Global Health (ISGlobal), Campus Mar, Barcelona Biomedical Research Park (PRBB), Dr Aiguader 88, 08003 Barcelona, Spain; University Pompeu Fabra, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Healt
  • de Vathaire F; Radiation Epidemiology Teams, INSERM Unit 1018, University Paris Saclay, Gustave Roussy, 94800 Villejuif, France.
  • Benotmane MA; Radiobiology Unit, Institute of Environment, Health and Safety, SCK CEN, Mol, Belgium.
  • Cardis E; Barcelona Institute for Global Health (ISGlobal), Campus Mar, Barcelona Biomedical Research Park (PRBB), Dr Aiguader 88, 08003 Barcelona, Spain; University Pompeu Fabra, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Healt
Environ Int ; 147: 106295, 2021 02.
Article em En | MEDLINE | ID: mdl-33341586
ABSTRACT
The last decades have seen increased concern about the possible effects of low to moderate doses of ionizing radiation (IR) exposure on cognitive function. An interdisciplinary group of experts (biologists, epidemiologists, dosimetrists and clinicians) in this field gathered together in the framework of the European MELODI workshop on non-cancer effects of IR to summarise the state of knowledge on the topic and elaborate research recommendations for future studies in this area. Overall, there is evidence of cognitive effects from low IR doses both from biology and epidemiology, though a better characterization of effects and understanding of mechanisms is needed. There is a need to better describe the specific cognitive function or diseases that may be affected by radiation exposure. Such cognitive deficit characterization should consider the human life span, as effects might differ with age at exposure and at outcome assessment. Measurements of biomarkers, including imaging, will likely help our understanding on the mechanism of cognitive-related radiation induced deficit. The identification of loci of individual genetic susceptibility and the study of gene expression may help identify individuals at higher risk. The mechanisms behind the radiation induced cognitive effects are not clear and are likely to involve several biological pathways and different cell types. Well conducted research in large epidemiological cohorts and experimental studies in appropriate animal models are needed to improve the understanding of radiation-induced cognitive effects. Results may then be translated into recommendations for clinical radiation oncology and imaging decision making processes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões por Radiação / Exposição à Radiação Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Environ Int Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões por Radiação / Exposição à Radiação Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Environ Int Ano de publicação: 2021 Tipo de documento: Article