Linezolid Induced Lactic Acidosis: The Side Effect, Clinician Should Be Aware of.
Cureus
; 12(11): e11514, 2020 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-33354458
ABSTRACT
Linezolid is a synthetic antibiotic that functions through the inhibition of bacterial protein synthesis by binding to ribosomal ribonucleic acid (rRNA). Deliverable in both intravenous and oral form, with a low level of resistance amongst Methicillin-resistant Staphylococcus aureus (MRSA) strains, it is recommended for a wide range of gram-positive infections. We present a case of a male patient who underwent endovascular abdominal aortic aneurysm repair complicated by abdominal sepsis due to bowel ischemia; several days after linezolid therapy was initiated, he presented with signs of lactic acidosis. After excluding other sources such as metabolic, hypoxia, or organ damage, the resulting lactic acidosis was determined to be a side effect of linezolid.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Cureus
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos