Identification of novel CD44v6-binding peptides that block CD44v6 and deliver a pro-apoptotic peptide to tumors to inhibit tumor growth and metastasis in mice.

Khan, Fatima; Gurung, Smriti; Gunassekaran, Gowri Rangaswamy; Vadevoo, Sri Murugan Poongkavithai; Chi, Lianhua; Permpoon, Uttapol; Haque, Md Enamul; Lee, Yun-Ki; Lee, Soo-Woong; Kim, Soyoun; Lee, Byungheon

Khan, Fatima; Gurung, Smriti; Gunassekaran, Gowri Rangaswamy; Vadevoo, Sri Murugan Poongkavithai; Chi, Lianhua; Permpoon, Uttapol; Haque, Md Enamul; Lee, Yun-Ki; Lee, Soo-Woong; Kim, Soyoun; Lee, Byungheon.

Afiliação

Khan F; Department of Biochemistry and Cell Biology, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Gurung S; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Gunassekaran GR; CMRI, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Vadevoo SMP; Department of Biochemistry and Cell Biology, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Chi L; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Permpoon U; Department of Biochemistry and Cell Biology, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Haque ME; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Lee YK; Department of Biochemistry and Cell Biology, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Lee SW; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Kim S; Department of Biochemistry and Cell Biology, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
Lee B; Department of Biochemistry and Cell Biology, School Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.

Theranostics ; 11(3): 1326-1344, 2021.

Article em En | MEDLINE | ID: mdl-33391537

Assuntos

Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Receptores de Hialuronatos/metabolismo; Metástase Neoplásica/prevenção & controle; Peptídeos/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Animais; Linhagem Celular; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Crizotinibe/farmacologia; Feminino; Células HEK293; Fator de Crescimento de Hepatócito/metabolismo; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Células MCF-7; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Proteínas Proto-Oncogênicas c-met/metabolismo; Regulação para Cima/efeitos dos fármacos

Palavras-chave

CD44v6; c-Met; metastasis; peptide; phage display

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Apoptose / Receptores de Hialuronatos / Inibidores de Proteínas Quinases / Proliferação de Células / Metástase Neoplásica Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Theranostics Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google