Your browser doesn't support javascript.
loading
Analysis of urinary exosomes applications for rare kidney disorders.
Panfoli, Isabella; Granata, Simona; Candiano, Giovanni; Verlato, Alberto; Lombardi, Gianmarco; Bruschi, Maurizio; Zaza, Gianluigi.
Afiliação
  • Panfoli I; Department of Pharmacy-DIFAR, University of Genoa , Genoa, Italy.
  • Granata S; Renal Unit, Department of Medicine, University-Hospital of Verona , Verona, Italy.
  • Candiano G; Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini , Genoa, Italy.
  • Verlato A; Renal Unit, Department of Medicine, University-Hospital of Verona , Verona, Italy.
  • Lombardi G; Renal Unit, Department of Medicine, University-Hospital of Verona , Verona, Italy.
  • Bruschi M; Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini , Genoa, Italy.
  • Zaza G; Renal Unit, Department of Medicine, University-Hospital of Verona , Verona, Italy.
Expert Rev Proteomics ; 17(10): 735-749, 2020 10.
Article em En | MEDLINE | ID: mdl-33395324
Introduction: Exosomes are nanovesicles that play important functions in a variety of physiological and pathological conditions. They are powerful cell-to-cell communication tool thanks to the protein, mRNA, miRNA, and lipid cargoes they carry. They are also emerging as valuable diagnostic and prognostic biomarker sources. Urinary exosomes carry information from all the cells of the urinary tract, downstream of the podocyte. Rare kidney diseases are a subset of an inherited diseases whose genetic diagnosis can be unclear, and presentation can vary due to genetic, epigenetic, and environmental factors. Areas covered: In this review, we focus on a group of rare and often neglected kidney diseases, for which we have sufficient available literature data on urinary exosomes. The analysis of their content can help to comprehend pathological mechanisms and to identify biomarkers for diagnosis, prognosis, and therapeutic targets. Expert opinion: The foreseeable large-scale application of system biology approach to the profiling of exosomal proteins as a source of renal disease biomarkers will be also useful to stratify patients with rare kidney diseases whose penetrance, phenotypic presentation, and age of onset vary sensibly. This can ameliorate the clinical management.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exossomos / Nefropatias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Expert Rev Proteomics Assunto da revista: BIOQUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exossomos / Nefropatias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Expert Rev Proteomics Assunto da revista: BIOQUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália