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Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae.
Lacerna, Noel M; Ramones, Cydee Marie V; Robes, Jose Miguel D; Picart, Myra Ruth D; Tun, Jortan O; Miller, Bailey W; Haygood, Margo G; Schmidt, Eric W; Salvador-Reyes, Lilibeth A; Concepcion, Gisela P.
Afiliação
  • Lacerna NM; The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
  • Ramones CMV; The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
  • Robes JMD; The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
  • Picart MRD; The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
  • Tun JO; The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
  • Miller BW; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
  • Haygood MG; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
  • Schmidt EW; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
  • Salvador-Reyes LA; The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
  • Concepcion GP; The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.
Mar Drugs ; 18(12)2020 Dec 20.
Article em En | MEDLINE | ID: mdl-33419303
ABSTRACT
The bioactivity-guided purification of the culture broth of the shipworm endosymbiont Teredinibacter turnerae strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (1), and two previously described oxylipins (2-3). Turneroic acid (1) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds 1-3 inhibited bacterial biofilm formation in Staphylococcus epidermidis, while only 3 showed antimicrobial activity against planktonic S. epidermidis. Comparison of the bioactivity of 1-3 with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simbiose / Biofilmes / Gammaproteobacteria / Oxilipinas Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Filipinas
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simbiose / Biofilmes / Gammaproteobacteria / Oxilipinas Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Filipinas