STEP inhibition prevents Aß-mediated damage in dendritic complexity and spine density in Alzheimer's disease.

Chatterjee, Manavi; Kwon, Jeemin; Benedict, Jessie; Kamceva, Marija; Kurup, Pradeep; Lombroso, Paul J

Chatterjee, Manavi; Kwon, Jeemin; Benedict, Jessie; Kamceva, Marija; Kurup, Pradeep; Lombroso, Paul J.

Afiliação

Chatterjee M; Child Study Center, Yale University, 230 South Frontage Rd, New Haven, CT, 06520, USA. manavi.chatterjee@yale.edu.
Kwon J; Child Study Center, Yale University, 230 South Frontage Rd, New Haven, CT, 06520, USA.
Benedict J; Child Study Center, Yale University, 230 South Frontage Rd, New Haven, CT, 06520, USA.
Kamceva M; Child Study Center, Yale University, 230 South Frontage Rd, New Haven, CT, 06520, USA.
Kurup P; Child Study Center, Yale University, 230 South Frontage Rd, New Haven, CT, 06520, USA.
Lombroso PJ; Department of Surgery, University of Alabama at Birmingham, 1900 University Blvd, Birmingham, AL, 35233, United States.

Exp Brain Res ; 239(3): 881-890, 2021 Mar.

Article em En | MEDLINE | ID: mdl-33420799

Assuntos

Doença de Alzheimer; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/genética; Animais; Modelos Animais de Doenças; Hipocampo; Memória; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos

Palavras-chave

Alzheimer's disease; Dendritic complexity; STEP; Spine density; TC-2153

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Animals Idioma: En Revista: Exp Brain Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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