KHDRBS3 promotes multi-drug resistance and anchorage-independent growth in colorectal cancer.

Ukai, Shoichi; Sakamoto, Naoya; Taniyama, Daiki; Harada, Kenji; Honma, Ririno; Maruyama, Ryota; Naka, Kazuhito; Hinoi, Takao; Takakura, Yuji; Shimizu, Wataru; Ohdan, Hideki; Yasui, Wataru

Ukai, Shoichi; Sakamoto, Naoya; Taniyama, Daiki; Harada, Kenji; Honma, Ririno; Maruyama, Ryota; Naka, Kazuhito; Hinoi, Takao; Takakura, Yuji; Shimizu, Wataru; Ohdan, Hideki; Yasui, Wataru.

Afiliação

Ukai S; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Sakamoto N; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Taniyama D; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Harada K; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Honma R; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Maruyama R; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Naka K; Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Hinoi T; Department of Clinical and Molecular Genetics, Hiroshima University Hospital, Hiroshima, Japan.
Takakura Y; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shimizu W; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Ohdan H; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yasui W; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Cancer Sci ; 112(3): 1196-1208, 2021 Mar.

Article em En | MEDLINE | ID: mdl-33423358

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Neoplasias Colorretais/terapia; Resistência a Múltiplos Medicamentos/genética; Resistencia a Medicamentos Antineoplásicos/genética; Proteínas de Ligação a RNA/metabolismo; Idoso; Idoso de 80 Anos ou mais; Animais; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Linhagem Celular Tumoral; Colectomia; Colo/patologia; Colo/cirurgia; Neoplasias Colorretais/genética; Neoplasias Colorretais/mortalidade; Neoplasias Colorretais/patologia; Feminino; Fluoruracila/farmacologia; Fluoruracila/uso terapêutico; Regulação Neoplásica da Expressão Gênica; Técnicas de Inativação de Genes; Humanos; Receptores de Hialuronatos/genética; Masculino; Camundongos; Pessoa de Meia-Idade; Mutação; Células-Tronco Neoplásicas/patologia; Organoides/efeitos dos fármacos; Organoides/metabolismo; Prognóstico; Proteínas Proto-Oncogênicas p21(ras)/genética; Proteínas de Ligação a RNA/genética; Análise de Sobrevida; Via de Sinalização Wnt/genética; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

5-FU; KHDRBS3; cancer stem cell; colorectal cancer; drug resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Proteínas de Ligação a RNA / Resistência a Múltiplos Medicamentos / Resistencia a Medicamentos Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Aged80 Idioma: En Revista: Cancer Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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