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A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights.
Al-Sanea, Mohammad M; Obaidullah, Ahmad J; Shaker, Mohamed E; Chilingaryan, Garri; Alanazi, Mohammed M; Alsaif, Nawaf A; Alkahtani, Hamad M; Alsubaie, Sultan A; Abdelgawad, Mohamed A.
Afiliação
  • Al-Sanea MM; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Aljouf Province, Saudi Arabia.
  • Obaidullah AJ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Shaker ME; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia.
  • Chilingaryan G; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
  • Alanazi MM; Institute of Biomedicine and Pharmacy, Russian-Armenian University, Yerevan 0051, Armenia.
  • Alsaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Alkahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Alsubaie SA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Molecules ; 26(2)2021 Jan 14.
Article em En | MEDLINE | ID: mdl-33466812
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação por Computador / Neoplasias da Mama / Desenho de Fármacos / Apoptose / Inibidores de Proteínas Quinases / Quinase 2 Dependente de Ciclina / Hidrazonas / Indóis Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Female / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Arábia Saudita
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação por Computador / Neoplasias da Mama / Desenho de Fármacos / Apoptose / Inibidores de Proteínas Quinases / Quinase 2 Dependente de Ciclina / Hidrazonas / Indóis Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Female / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Arábia Saudita