PFRED: A computational platform for siRNA and antisense oligonucleotides design.
PLoS One
; 16(1): e0238753, 2021.
Article
em En
| MEDLINE
| ID: mdl-33481821
ABSTRACT
PFRED a software application for the design, analysis, and visualization of antisense oligonucleotides and siRNA is described. The software provides an intuitive user-interface for scientists to design a library of siRNA or antisense oligonucleotides that target a specific gene of interest. Moreover, the tool facilitates the incorporation of various design criteria that have been shown to be important for stability and potency. PFRED has been made available as an open-source project so the code can be easily modified to address the future needs of the oligonucleotide research community. A compiled version is available for downloading at https//github.com/pfred/pfred-gui/releases/tag/v1.0 as a java Jar file. The source code and the links for downloading the precompiled version can be found at https//github.com/pfred.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos Antissenso
/
Primers do DNA
/
Biologia Computacional
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos