Systemic diseases and the cornea.
Exp Eye Res
; 204: 108455, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33485845
ABSTRACT
There is a number of systemic diseases affecting the cornea. These include endocrine disorders (diabetes, Graves' disease, Addison's disease, hyperparathyroidism), infections with viruses (SARS-CoV-2, herpes simplex, varicella zoster, HTLV-1, Epstein-Barr virus) and bacteria (tuberculosis, syphilis and Pseudomonas aeruginosa), autoimmune and inflammatory diseases (rheumatoid arthritis, Sjögren's syndrome, lupus erythematosus, gout, atopic and vernal keratoconjunctivitis, multiple sclerosis, granulomatosis with polyangiitis, sarcoidosis, Cogan's syndrome, immunobullous diseases), corneal deposit disorders (Wilson's disease, cystinosis, Fabry disease, Meretoja's syndrome, mucopolysaccharidosis, hyperlipoproteinemia), and genetic disorders (aniridia, Ehlers-Danlos syndromes, Marfan syndrome). Corneal manifestations often provide an insight to underlying systemic diseases and can act as the first indicator of an undiagnosed systemic condition. Routine eye exams can bring attention to potentially life-threatening illnesses. In this review, we provide a fairly detailed overview of the pathologic changes in the cornea described in various systemic diseases and also discuss underlying molecular mechanisms, as well as current and emerging treatments.
Palavras-chave
Addison's disease; Aniridia; Autoimmune disease; Corneal deposit disorder; Diabetic cornea; Ehlers-Danlos syndrome; Genetic corneal disease; Graves' disease; Herpes; Immunobullous disease; Inflammation; Keratoconjunctivitis; Marfan syndrome; Pseudomonas aeruginosa; SARS-CoV-2; Sjögren's syndrome; Syphilis; Tuberculosis; Zoster
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Córnea
/
COVID-19
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Exp Eye Res
Ano de publicação:
2021
Tipo de documento:
Article