Fluorophosphonates on-Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis.
Chembiochem
; 22(10): 1769-1774, 2021 05 14.
Article
em En
| MEDLINE
| ID: mdl-33491295
ABSTRACT
Herein, we report a general and simplified synthesis of fluorophosphonates directly from p-nitrophenylphosphonates. This FP on-demand reaction is mediated by a commercially available polymer-supported fluoride reagent that produces a variety (25 examples) of fluorophosphonates in high yields while only requiring reagent filtration for pure fluorophosphonate isolation. This reaction protocol facilitates the rapid profiling of serine hydrolases with diverse and novel sets of activated phosphonates with differential proteome reactivity. Moreover, slight modification of the procedure into a reaction-to-assay format has enabled additional screening efficiency.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Organofosfonatos
/
Flúor
Limite:
Humans
Idioma:
En
Revista:
Chembiochem
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos