The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease.
Obesity (Silver Spring)
; 29(2): 428-437, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33491305
ABSTRACT
OBJECTIVE:
This study aimed to investigate the role of cytokines as intermediates in the pathway from increased adiposity to disease.METHODS:
BMI and circulating levels of up to 41 cytokines were measured in individuals from three Finnish cohort studies (n = 8,293). Mendelian randomization (MR) was used to assess the impact of BMI on circulating cytokines and the impact of BMI-driven cytokines on risk of obesity-related diseases.RESULTS:
Observationally, BMI was associated with 19 cytokines. For every SD increase in BMI, causal effect estimates were strongest for hepatocyte growth factor, monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and were as ratios of geometric means 1.13 (95% CI 1.08-1.19), 1.08 (95% CI 1.04-1.14), and 1.13 (95% CI 1.04-1.21), respectively. TRAIL was associated with a small increase in the odds of coronary artery disease (odds ratio 1.03; 95% CI 1.00-1.06). There was inconsistent evidence for a protective role of MCP-1 against inflammatory bowel diseases.CONCLUSIONS:
Observational and MR estimates of the effect of BMI on cytokine levels were generally concordant. There was little evidence for an effect of raised levels of BMI-driven cytokines on disease. These findings illustrate the challenges of MR when applied in the context of molecular mediation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Adiposidade
/
Obesidade
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Obesity (Silver Spring)
Assunto da revista:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
METABOLISMO
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Finlândia