The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer.

Deegen, Petra; Thomas, Oliver; Nolan-Stevaux, Olivier; Li, Shyun; Wahl, Joachim; Bogner, Pamela; Aeffner, Famke; Friedrich, Matthias; Liao, Michael Z; Matthes, Katja; Rau, Doris; Rattel, Benno; Raum, Tobias; Kufer, Peter; Coxon, Angela; Bailis, Julie M

Deegen, Petra; Thomas, Oliver; Nolan-Stevaux, Olivier; Li, Shyun; Wahl, Joachim; Bogner, Pamela; Aeffner, Famke; Friedrich, Matthias; Liao, Michael Z; Matthes, Katja; Rau, Doris; Rattel, Benno; Raum, Tobias; Kufer, Peter; Coxon, Angela; Bailis, Julie M.

Afiliação

Deegen P; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
Thomas O; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
Nolan-Stevaux O; Oncology Research, Amgen Research, South San Francisco, California.
Li S; Oncology Research, Amgen Research, South San Francisco, California.
Wahl J; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
Bogner P; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
Aeffner F; Translational Safety & Bioanalytical Sciences, Amgen Research, South San Francisco, California.
Friedrich M; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
Liao MZ; Clinical Pharmacology, Modeling & Simulation, South San Francisco, California.
Matthes K; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
Rau D; Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, Germany.
Rattel B; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
Raum T; Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, Germany.
Kufer P; Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, Germany.
Coxon A; Oncology Research, Amgen Research, Thousand Oaks, California.
Bailis JM; Oncology Research, Amgen Research, South San Francisco, California. jbailis@amgen.com.

Clin Cancer Res ; 27(10): 2928-2937, 2021 05 15.

Article em En | MEDLINE | ID: mdl-33504551

Assuntos

Transferência Adotiva/métodos; Antígenos de Superfície/imunologia; Glutamato Carboxipeptidase II/imunologia; Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico; Neoplasias de Próstata Resistentes à Castração/metabolismo; Linfócitos T/imunologia; Animais; Complexo CD3/antagonistas & inibidores; Complexo CD3/imunologia; Complexo CD3/metabolismo; Linhagem Celular Tumoral; Citocinas/metabolismo; Citotoxicidade Imunológica; Modelos Animais de Doenças; Relação Dose-Resposta Imunológica; Glutamato Carboxipeptidase II/antagonistas & inibidores; Humanos; Ativação Linfocitária/imunologia; Masculino; Camundongos; Neoplasias de Próstata Resistentes à Castração/patologia; Linfócitos T/metabolismo; Resultado do Tratamento; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Transferência Adotiva / Glutamato Carboxipeptidase II / Neoplasias de Próstata Resistentes à Castração / Antígenos de Superfície Limite: Animals / Humans / Male Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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