Cytoplasmic chromatin fragments-from mechanisms to therapeutic potential.
Elife
; 102021 01 29.
Article
em En
| MEDLINE
| ID: mdl-33512316
ABSTRACT
Senescent cells, damaged cells that permanently exit the cell cycle, play important roles in development, tissue homeostasis, and tumorigenesis. Although many of these roles are beneficial in acute responses to stress and damage, the persistent accumulation of senescent cells is associated with many chronic diseases through their proinflammatory senescence-associated secretory phenotype (SASP). SASP expression is linked to DNA damage; however, the mechanisms that control the SASP are incompletely understood. More recently, it has been shown that senescent cells shed fragments of nuclear chromatin into the cytoplasm, so called cytoplasmic chromatin fragments (CCF). Here, we provide an overview of the current evidence linking DNA damage to the SASP through the formation of CCF. We describe mechanisms of CCF generation and their functional role in senescent cells, with emphasis on therapeutic potential.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
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Cromatina
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Senescência Celular
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Fenótipo Secretor Associado à Senescência
Idioma:
En
Revista:
Elife
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos