Molecular Epidemiology of Measles in California, United States-2019.
J Infect Dis
; 224(6): 1015-1023, 2021 09 17.
Article
em En
| MEDLINE
| ID: mdl-33528506
ABSTRACT
In 2019, the United States (US) experienced the highest number of measles importations and cases in the postelimination era. More than a quarter of imported cases entered the US through California. Measles surveillance efforts in California resulted in the identification of 26 importations, 6 outbreaks, and 72 cases in 2019. Only genotype B3 and D8 measles strains were detected. Genotype-specific differences were noted in the incidence of vaccine failures, hospitalizations, and severe complications among cases. A targeted whole genome sequencing approach provided higher-resolution discrimination between epidemiologically linked and sporadically introduced strains than conventional N450 sequencing. Our report underscores the importance of ensuring appropriate measles vaccination status, especially prior to international travel to measles-endemic regions, and highlights the value of a strong measles surveillance system in minimizing outbreaks and preserving measles elimination status in the US.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacina contra Sarampo
/
Surtos de Doenças
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Sarampo
/
Vírus do Sarampo
Tipo de estudo:
Screening_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos