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Inotuzumab ozogamicin in infants and young children with relapsed or refractory acute lymphoblastic leukaemia: a case series.
Brivio, Erica; Chantrain, Christophe F; Gruber, Tanja A; Thano, Adriana; Rialland, Fanny; Contet, Audrey; Elitzur, Sarah; Dalla-Pozza, Luciano; Kállay, Krisztián Miklós; Li, Chi-Kong; Kato, Motohiro; Markova, Inna; Schmiegelow, Kjeld; Bodmer, Nicole; Breese, Erin H; Hoogendijk, Raoull; Pieters, Rob; Zwaan, Christian Michel.
Afiliação
  • Brivio E; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Chantrain CF; Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
  • Gruber TA; Division of Pediatric Hematology Oncology, CHC-Clinique du MontLégia - Liège, Liège, Belgium.
  • Thano A; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA.
  • Rialland F; Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA, USA.
  • Contet A; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Elitzur S; Department of Oncology and Hematology, CHU de Nantes, Nantes, France.
  • Dalla-Pozza L; Department of Oncology and Hematology, Children's Hospital, CHRU Nancy, Vandoeuvre Lès Nancy, France.
  • Kállay KM; Pediatric Hematology -Oncology, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Li CK; Cancer Centre for Children, The Children's Hospital at Westmead, Westmead, Australia.
  • Kato M; Pediatric Hematology and Stem Cell Transplantation Department, Central Hospital of Southern Pest - National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
  • Markova I; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China.
  • Schmiegelow K; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Bodmer N; R.M. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, Pavlov University, Saint-Petersburg, Russia.
  • Breese EH; Department of Pediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital; Institute of Clinical Medicine, Faculty of Health, University of Copenhagen, Copenhagen, Denmark.
  • Hoogendijk R; Department Oncology, University Children's Hospital Zürich, Zürich, Switzerland.
  • Pieters R; Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Zwaan CM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Br J Haematol ; 193(6): 1172-1177, 2021 06.
Article em En | MEDLINE | ID: mdl-33529389
ABSTRACT
No data on inotuzumab ozogamicin (InO) in infant acute lymphoblastic leukaemia (ALL) have been published to date. We collected data internationally on infants/young children (<3 years) with ALL treated with InO. Fifteen patients (median 4.4 months at diagnosis) received InO due to relapsed or refractory (R/R) disease. Median percentage of CD22+ blasts was 72% (range 40-100%, n = 9). The median dose in the first course was 1.74 mg/m2 (fractionated). Seven patients (47%) achieved complete remission; one additional minimal residual disease (MRD)-positive patient became MRD-negative. Six-month overall survival was 47% (95% confidence interval [CI] 27-80%). Two patients developed veno-occlusive disease after transplant. Further evaluation of InO in this subgroup of ALL is justified.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Leucemia-Linfoma Linfoblástico de Células Precursoras / Inotuzumab Ozogamicina Limite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Br J Haematol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Leucemia-Linfoma Linfoblástico de Células Precursoras / Inotuzumab Ozogamicina Limite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Br J Haematol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda