[Research progress in gene therapy for Wilson's disease].
Zhonghua Gan Zang Bing Za Zhi
; 29(1): 21-24, 2021 Jan 20.
Article
em Zh
| MEDLINE
| ID: mdl-33541020
ABSTRACT
Wilson's disease (WD) is a kind of inherited single-gene autosomal recessive disorder in which mutations in the ATP7B gene cause copper excretion disorders. Drug therapy is currently the main treatment method for WD. Liver transplantation should be considered for poor drug response or acute liver failure. However, it faces problems such as medication adherence, adverse reactions and shortage of liver source. Gene therapy in WD may permanently correct abnormal copper metabolism, which is why it is the focus of current research. This article summarizes the research progress of WD around gene therapy vectors and CRISPR/Cas9 gene editing system.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Degeneração Hepatolenticular
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Gan Zang Bing Za Zhi
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China