Water-soluble triazole chitin derivative and its based nanoparticles: Synthesis, characterization, catalytic and antibacterial properties.
Carbohydr Polym
; 257: 117593, 2021 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-33541634
In this work, we treated chitin with 2-(azidomethyl)oxirane and successfully involved the resultant azido chitin derivatives in the ultrasound-assisted Cu(I)-catalyzed azido-alkyne click (CuAAC) reaction with propargylic ester of N,N,N-trimethyl glycine. Thus, we obtained novel water-soluble triazole chitin derivatives. The triazole chitin derivatives and their nanoparticles are characterized by a high in vitro antibacterial activity, which is the same or even higher than that of commercial antibiotics ampicillin and gentamicin. The obtained derivatives are non-toxic. Moreover, the obtained water-soluble polymers are highly efficient green catalysts for the aldol reaction in green solvent water. The catalysts can be easily extracted from the reaction mixture by its precipitation with green solvent ethanol followed by centrifugation and they can be reused at least 10 times.
Palavras-chave
Aldol reaction; Azido chitin derivatives; Betaine; Chitin; Chitosan; Click-chemistry; Copper(II) sulfate pentahydrate; Ionic gelation method; Lithium chloride; Nanoparticles; Propargyl alcohol; Propargylic ester of N,N,N-trimethyl glycine; Thionyl chloride 2-(azidomethyl)oxirane; Tripolyphosphate (TPP); diisopropylethylamine (DIEA)
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triazóis
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Quitosana
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Óxido de Etileno
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Nanopartículas
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Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2021
Tipo de documento:
Article