Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction.
Handb Exp Pharmacol
; 271: 315-350, 2022.
Article
em En
| MEDLINE
| ID: mdl-33547588
ABSTRACT
Pain is complex and is a unique experience for individuals in that no two people will have exactly the same physiological and emotional response to the same noxious stimulus or injury. Pain is composed of two essential processes a sensory component that allows for discrimination of the intensity and location of a painful stimulus and an emotional component that underlies the affective, motivational, unpleasant, and aversive response to a painful stimulus. Kappa opioid receptor (KOR) activation in the periphery and throughout the neuroaxis modulates both of these components of the pain experience. In this chapter we focus on recent findings that KORs contribute to the emotional, aversive nature of chronic pain, including how expression in the limbic circuitry contributes to anhedonic states and components of opioid misuse disorder. While the primary focus is on preclinical pain models, we also highlight clinical or human research where there is strong evidence for KOR involvement in negative affective states associated with chronic pain and opioid misuse.
Palavras-chave
Amygdala; Analgesia; Anhedonia; Antinociception; Biased agonist; Chronic pain; Dopamine; Dynorphin; Emotional component of pain; Endogenous opioid; Inflammatory pain; Kappa opioid receptor; Mesolimbic circuitry; Negative affect; Neuropathic pain; Nociception; Nucleus accumbens; Opioid misuse; Opioid use disorder; Pain; Pain aversion; Peripherally-restricted; Ventral tegmental area
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dor Crônica
/
Transtornos Relacionados ao Uso de Opioides
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Handb Exp Pharmacol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos