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Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination.
Paixão, Vitória; Almeida, Ewin B; Amaral, Jonatas B; Roseira, Tamaris; Monteiro, Fernanda R; Foster, Roberta; Sperandio, Adriane; Rossi, Marcelo; Amirato, Gislene R; Santos, Carlos A F; Pires, Renier S; Leal, Fabyano B; Durigon, Edison L; Oliveira, Danielle B L; Vieira, Rodolfo P; Vaisberg, Mauro; Santos, Juliana M B; Bachi, André L L.
Afiliação
  • Paixão V; Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
  • Almeida EB; Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
  • Amaral JB; Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
  • Roseira T; Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
  • Monteiro FR; Method Faculty of São Paulo (FAMESP), São Paulo 04046-200, Brazil.
  • Foster R; Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
  • Sperandio A; Method Faculty of São Paulo (FAMESP), São Paulo 04046-200, Brazil.
  • Rossi M; Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
  • Amirato GR; Method Faculty of São Paulo (FAMESP), São Paulo 04046-200, Brazil.
  • Santos CAF; Method Faculty of São Paulo (FAMESP), São Paulo 04046-200, Brazil.
  • Pires RS; Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
  • Leal FB; Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil.
  • Durigon EL; Department of Medicine, Geriatry, Paulista School of Medicine (EPM), São Paulo 04023-062, Brazil.
  • Oliveira DBL; Post-Graduation Program in Health Science, Santo Amaro University (UNISA), São Paulo 04743-030, Brazil.
  • Vieira RP; Institute of Biomedical Science, University of São Paulo (USP), São Paulo 05508-060, Brazil.
  • Vaisberg M; Institute of Biomedical Science, University of São Paulo (USP), São Paulo 05508-060, Brazil.
  • Santos JMB; Scientific Platform Pasteur, University of São Paulo (USP), São Paulo 05508-060, Brazil.
  • Bachi ALL; Institute of Biomedical Science, University of São Paulo (USP), São Paulo 05508-060, Brazil.
Vaccines (Basel) ; 9(2)2021 Jan 31.
Article em En | MEDLINE | ID: mdl-33572639
BACKGROUND: Although glutamine is able to improve the immune response, its action in the upper airway immunity against the influenza virus vaccine remains unclear. Therefore, we aimed to evaluate the L-glutamine supplementation effect on the mucosal immune/inflammatory response of elderly subjects vaccinated against the influenza virus. METHODS: Saliva sampling from 83 physically active elderly volunteers were collected pre- and 30 days after influenza virus vaccination and supplementation with L-glutamine (Gln, n = 42) or placebo (PL, n = 41). RESULTS: Gln group showed higher salivary levels of interleukin (IL)-17, total secretory immunoglobulin A (SIgA), and specific-SIgA post-vaccination than values found pre-vaccination and in the PL group post-vaccination. Whereas higher salivary levels of IL-6 and IL-10 were observed post-vaccination in the Gln group, IL-37 levels were lower post-vaccination in both groups than the values pre-vaccination. Tumor necrosis factor (TNF)-α levels were unchanged. Positive correlations between IL-6 and IL-10 were found in all volunteer groups pre- and post-vaccination and also between IL-17 and IL-6 or IL-10 in the Gln group post-vaccination. A negative correlation between IL-37 and IL-10 was found pre- and post-vaccination in the PL group. CONCLUSION: Gln supplementation was able to modulate salivary cytokine profile and increase SIgA levels, both total and specific to the influenza virus vaccine, in physically active elderly subjects.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Vaccines (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Vaccines (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil