Evaluation of repeat testing of a non-sequencing based NIPT test on a Finnish general-risk population.
Acta Obstet Gynecol Scand
; 100(8): 1497-1500, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-33576010
ABSTRACT
INTRODUCTION:
To evaluate the effect of repeating test failures using an automated, non-sequencing based non-invasive prenatal testing test on a general-risk population in Finland. MATERIAL ANDMETHODS:
A total of 545 samples from women who represent the average-risk population in Oulu, Finland were analyzed with Vanadis® non-invasive prenatal testing. Repeat testing of test failures was performed using a second sample. Results before and after repeat testing were compared with the reference outcome, as determined by clinical examination of neonates.RESULTS:
There were eight test failures after first-pass analysis, representing 1.5% of samples (95% CI 0.6%-2.9%). Seven out of eight failures could be resolved by analysis of a second sample, thereby reducing the test failure rate from 1.5% to 0.2% (95% CI 0.0%-1.0%).CONCLUSIONS:
Repeating test failures with a second plasma sample could significantly reduce the effective failure rate, thereby providing a way to effectively minimize test failures and further improving clinical utility and test performance.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Natal
/
Testes Genéticos
/
Erros de Diagnóstico
/
Síndrome da Trissomia do Cromossomo 13
/
Síndrome da Trissomía do Cromossomo 18
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Acta Obstet Gynecol Scand
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Suécia