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AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts.
Yap, Jennifer Maries Go; Ueda, Takashi; Kanemitsu, Yoshihiro; Takeda, Norihisa; Fukumitsu, Kensuke; Fukuda, Satoshi; Uemura, Takehiro; Tajiri, Tomoko; Ohkubo, Hirotsugu; Maeno, Ken; Ito, Yutaka; Oguri, Testsuya; Ugawa, Shinya; Niimi, Akio.
Afiliação
  • Yap JMG; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Ueda T; Department of Anatomy and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
  • Kanemitsu Y; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan. kaney32@med.nagoya-cu.ac.jp.
  • Takeda N; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Fukumitsu K; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Fukuda S; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Uemura T; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Tajiri T; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Ohkubo H; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Maeno K; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Ito Y; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Oguri T; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Ugawa S; Department of Anatomy and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
  • Niimi A; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Respir Res ; 22(1): 51, 2021 Feb 12.
Article em En | MEDLINE | ID: mdl-33579280
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corticosteroides / Isotiocianatos / Quinases de Proteína Quinase Ativadas por Mitógeno / Heme Oxigenase-1 / Fator 2 Relacionado a NF-E2 / Canal de Cátion TRPA1 / Pulmão Limite: Humans Idioma: En Revista: Respir Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corticosteroides / Isotiocianatos / Quinases de Proteína Quinase Ativadas por Mitógeno / Heme Oxigenase-1 / Fator 2 Relacionado a NF-E2 / Canal de Cátion TRPA1 / Pulmão Limite: Humans Idioma: En Revista: Respir Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão